Drug fever

Fra NeuroWiki
Spring til navigation Spring til søgning

Lægemiddelinduceret feber (drug fever)

  • Bør altid overvejes ved uklare febertilstande
  • Vedvarende feber
  • C-reaktivt protein (CRP) i lavt område
  • eosinofili

Patienten får almindeligvis feber 3-5 dage efter påbegyndt behandling, men feberen kan af og til komme senere

Aktuelle medikamenter er:

  • Meronem
  • penicilliner
  • cefalosporiner
  • fenytoin
  • salicylater
  • sulfonamider
  • allopurinol
  • antihistaminer
  • cimetidin
  • isoniazid
  • prokainamid

Wikipedia.org

Drug-induced fever is a state wherein the administration of drugs intended to help a patient causes a fever. The drug may interfere with heat dissipation peripherally, increase the rate of metabolism, evoke a cellular or humoral immune response, mimic endogenous pyrogen, or damage tissues.

Triggers

  • Directly caused by the drug, e.g. lamictal, progesterone, or chemotherapeutics causing tumor necrosis
  • Possible side effect of stimulants and entactogens (e.g. MDMA, methamphetamine, PMA, 4-MTA)
  • As an adverse reaction to drugs, e.g. antibiotics or sulfa drugs.
  • After drug discontinuation, e.g. heroin or fentanyl withdrawal
  • Neuroleptic Malignant Syndrome; rare, life-threatening hyperpyrexia caused by antidopaminergic drugs (mostly antipsychotics)
  • Serotonin Syndrome; excessive serotonergic activity due usually to combined use of serotonergic drugs (e.g. antidepressants, stimulants, triptans)
  • 5HT2A agonists, e.g. psilocybin or LSD

External links

Drug Induced Fever information at PubMed