Drug fever
Lægemiddelinduceret feber (drug fever)
Bør altid overvejes ved uklare febertilstande. Vedvarende feber + C-reaktivt protein (CRP) i lavt område tyder på drug-fever.
Patienten får almindeligvis feber 3-5 dage efter påbegyndt behandling, men feberen kan af og til komme senere
Aktuelle medikamenter er:
- penicilliner
- cefalosporiner
- fenytoin
- salicylater
- sulfonamider
- allopurinol
- antihistaminer
- cimetidin
- isoniazid
- prokainamid
Drug-induced fever is a state wherein the administration of drugs intended to help a patient causes a fever. The drug may interfere with heat dissipation peripherally, increase the rate of metabolism, evoke a cellular or humoral immune response, mimic endogenous pyrogen, or damage tissues.
Triggers
- Directly caused by the drug, e.g. lamictal, progesterone, or chemotherapeutics causing tumor necrosis
- Possible side effect of stimulants and entactogens (e.g. MDMA, methamphetamine, PMA, 4-MTA)
- As an adverse reaction to drugs, e.g. antibiotics or sulfa drugs.
- After drug discontinuation, e.g. heroin or fentanyl withdrawal
- Neuroleptic Malignant Syndrome; rare, life-threatening hyperpyrexia caused by antidopaminergic drugs (mostly antipsychotics)
- Serotonin Syndrome; excessive serotonergic activity due usually to combined use of serotonergic drugs (e.g. antidepressants, stimulants, triptans)
- 5HT2A agonists, e.g. psilocybin or LSD
