Drug fever

Lægemiddelinduceret feber (drug fever)

Bør altid overvejes ved uklare febertilstande. Vedvarende feber + C-reaktivt protein (CRP) i lavt område tyder på drug-fever.

Patienten får almindeligvis feber 3-5 dage efter påbegyndt behandling, men feberen kan af og til komme senere

Aktuelle medikamenter er:

• penicilliner
• cefalosporiner
• fenytoin
• salicylater
• sulfonamider
• allopurinol
• antihistaminer
• cimetidin
• isoniazid
• prokainamid

Drug-induced fever is a state wherein the administration of drugs intended to help a patient causes a fever. The drug may interfere with heat dissipation peripherally, increase the rate of metabolism, evoke a cellular or humoral immune response, mimic endogenous pyrogen, or damage tissues.

Triggers

• Directly caused by the drug, e.g. lamictal, progesterone, or chemotherapeutics causing tumor necrosis
• Possible side effect of stimulants and entactogens (e.g. MDMA, methamphetamine, PMA, 4-MTA)
• As an adverse reaction to drugs, e.g. antibiotics or sulfa drugs.
• After drug discontinuation, e.g. heroin or fentanyl withdrawal
• Neuroleptic Malignant Syndrome; rare, life-threatening hyperpyrexia caused by antidopaminergic drugs (mostly antipsychotics)
• Serotonin Syndrome; excessive serotonergic activity due usually to combined use of serotonergic drugs (e.g. antidepressants, stimulants, triptans)
• 5HT2A agonists, e.g. psilocybin or LSD

External links

Drug Induced Fever information at PubMed